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Onco Checklist >> CML Staging

 


DiagnosisResult
Bone marrow aspiration and biopsy 
Peripheral blood smears 
Immunophenotyping 
Cytogenetics   
Molecular biology (bcr-abl) 
FISH 


Patient historyResult
 Weight loss 
 Signs of bleeding, rheological disorders (TIA, cardiac ischemia, peripheral  circulatory disorder, headaches) 
 ECOG / Karnofsky-Index 
 Concomitant diseases 


Physical examinationResult
 Lymph nodes, heart-/lung, abdominal examination, edema? 
 Extramedullary disease (lymph node, skin) 
Spleen (cm below costal margin for risk score) 
 Liver (size in MCL) 
 Height and weight  
 Blood pressure and pulse 



Clinical chemistryResult
Blood count
Electrolytes
Creatinine
Creatinine clearance (calculated)
Liver enzymes (AST; ALT; G-GT)
Bilirubin
ESR
Alk phos
Coagulation parameters (incl. ATIII, D-dimers, fibrinogen)
LDH
CRP
Normoblasts
Eosinophils
Basophils
 


VirologyResult
 HIV 1 and 2 
 Hepatitis B 
 Hepatitis C 



Imaging and further examinationsResult
Chest X-ray  
Sonography of abdomen 
Echocardiography 
Spirometry 
EKG 


StudiesResult
 Inclusion in study possible?yes no
 Study:



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